Curriculum Vitae Dr. Christine Hacker

LinkedIn: https://www.linkedin.com/in/christine-hacker-438154152/

ResearchGate: https://www.researchgate.net/profile/Christine-Hacker

Personal Data 

Title                                        Dr. rer. nat.

First name                             Christine

Name                                     Hacker

Current position                     Science manager

ORCID                                   0000-0002-6545-0104

Qualifications and Career

Degree programme                

1990-1995, Chemistry, diploma, Technical University Berlin, Germany     

Doctorate                               

1995-1999, Dr. rer. nat., Methyltransferase domain of Enniatinsynthetase, supervisor: PD Dr. R. Zocher, Institute of Biochemistry, Technical University Berlin, Germany

Further stages                     

2017-present, scientific coordinator RTG2344, Institute of Anatomy and Cell Biology, University of Freiburg, Germany

2013-2017, postdoctoral fellow, supervisor: Prof. Dr. T.Vogel, Institute of Anatomy and Cell Biology, University of Freiburg, Germany

2008-2010, postdoctoral fellow, supervisor: Prof. Dr. K. Michels, tumour center, University clinics Freiburg, Germany

2006-2008, postdoctoral fellow, supervisor: Prof. Dr. B. Munz, Institute of Physiology, Charité Berlin, Germany

2000-2003, postdoctoral fellow, supervisor: Prof. Dr. M. Zenke, Max Delbrück Center, Berlin, Germany

Supplementary Career Information

3 children, *2003, 2005, 2011

04/2003- 08/2006 and 03/2011-03/2013 Maternal leave

2013-2017 part time work 50% 

Engagement in the Research System 

Supervision of Diploma and PhD students

Review for Cell Tissue Res

Science communication: represented my research groups on several fairs for public science communication 

Scientific management of RTG2344 (since 2017)

workshop leader for Good Scientific Practice (since 2021)

member of the Freiburg Graduate Center advisory board (since 2023)

Scientific Results

Akol I, Izzo A, Gather F, Strack S, Heidrich S, Ó hAilín D, Villarreal A, Hacker C, Rauleac T, Bella C, Fischer A, Manke T, Vogel T (2023) Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome. Proc Natl Acad Sci U S A. 120(2):e2122467120. doi: 10.1073/pnas.2122467120. 

Roidl D, Hacker C (2014) Histone methylation during neural development. Cell Tissue Res. 356(3):539-52. doi: 10.1007/s00441-014-1842-8.

Hacker C, Valchanova R, Adams S, Munz B (2010) ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. Growth Factors. 28(3):178-90. doi: 10.3109/08977190903578660. 

Gamper I, Koh KR, Ruau D, Ullrich K, Bartunkova J, Piroth D, Hacker C, Bartunek P, Zenke M (2009) GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells. Exp Hematol. 37(5):539-548.e4. doi: 10.1016/j.exphem.2009.02.002. 

Ruau D, Ensenat-Waser R, Dinger TC, Vallabhapurapu DS, Rolletschek A, Hacker C, Hieronymus T, Wobus AM, Müller AM, Zenke M (2008) Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. Stem Cells. 26(4):920-6. doi: 10.1634/stemcells.2007-0649. 

Busse M, Schwarzburger M, Berger F, Hacker C, Munz B (2008) Strong induction of the Tis11B gene in myogenic differentiation. Eur J Cell Biol. 87(1):31-8. doi: 10.1016/j.ejcb.2007.07.005. 

Prechtel AT, Turza NM, Kobelt DJ, Eisemann JI, Coffin RS, McGrath Y, Hacker C, Ju X, Zenke M, Steinkasserer A (2005) Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration. J Gen Virol. 86(Pt 6):1645-1657. doi: 10.1099/vir.0.80852-0. 

Ju XS, Hacker C, Scherer B, Redecke V, Berger T, Schuler G, Wagner H, Lipford GB, Zenke M (2004) Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation. Gene. 28;331:159-64. doi: 10.1016/j.gene.2004.02.018. 

Hacker C*, Kirsch RD*, Ju XS, Hieronymus T, Gust TC, Kuhl C, Jorgas T, Kurz SM, Rose-John S, Yokota Y, Zenke M (2003) Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol. 4(4):380-6. doi: 10.1038/ni903. *equal contribution

Hinz M, Lemke P, Anagnostopoulos I, Hacker C, Krappmann D, Mathas S, Dörken B, Zenke M, Stein H, Scheidereit C (2002) Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med. 196(5):605-17. doi: 10.1084/jem.20020062. 

Koritschoner NP, Alvarez-Dolado M, Kurz SM, Heikenwälder MF, Hacker C, Vogel F, Muñoz A, Zenke M (2001) Thyroid hormone regulates the obesity gene tub. EMBO Rep. 2(6):499-504. doi: 10.1093/embo-reports/kve107. 

Hacker C, Glinski M, Hornbogen T, Doller A, Zocher R (2000) Mutational analysis of the N-methyltransferase domain of the multifunctional enzyme enniatin synthetase. J Biol Chem. 275(40):30826-32. doi: 10.1074/jbc.M002614200. 

Zocher R, Weckwerth W, Hacker C, Kammer B, Hornbogen T, Ewald D (1996) Biosynthesis of taxol: enzymatic acetylation of 10-deacetylbaccatin-III to baccatin-III in crude extracts from roots of Taxus baccata. Biochem Biophys Res Commun. 229(1):16-20. doi: 10.1006/bbrc.1996.1751.